GIST·KBSI 공동연구팀, 항균 펩토이드 유효약물 발굴과 메커니즘 규명 성공“다제내성균에 효과적이면서 독성 낮춘 항균 치료제 유효물질 발굴”

저널 커버아트(프론트 인사이드 커버) 대표 이미지. 항균 펩토이드(분홍색) 의 다중 타겟 메커니즘을 통한 박테리아 사멸을 이미지화. ‘어드밴스드 사이언스(Advanced Science) 속표지(inside front cover) 선정. 광주과학기술원 서지원 교수 제공국내 연구진이 기존 항생제에 내성이 생긴 슈퍼박테리아를 잡는 강력한 항생제 약물을 발굴했다.한국연구재단은 광주과학기술원(GIST) 서지원 교수와 한국기초과학지원연구원(KBSI) 이성수 박사 공동연구팀이 ‘다제내성균에 효과적이면서 독성을 낮춘 항균 치료제 유효물질’을 발굴했다고 2일 밝혔다.항생제에 내성이 생긴 슈퍼박테리아 감염은 코로나바이러스처럼 전염속도가 빠르지는 않지만, 한 번 감염되면 치명률은 훨씬 높다.

그림. 3차원 홀로토모그래피 활용 다제내성균 치료 항생제 원리 규명. 항균 펩토이드에 의한 세포막 파괴 및 세포 내 단백질/핵산 응집 원리. 이를 굴절률 기반 3차원 실시간 균주 단층촬영을 통해 직접적으로 규명함. 광주과학기술원 서지원 교수 제공세계보건기구(WHO)는 다제내성균(여러 항생제에 내성이 있어 감염병 치료를 위해 사용할 수 있는 항생제가 제한적인 세균)에 의한 사망자가 2050년 연간 1000만 명에 이를 것으로 추산했다. 이는 지난해 암으로 인한 사망자 수와 맞먹는 수치이다.2016년 미국에서 인류가 가진 모든 항생제에 내성을 갖는 다제내성균이 발견되었고, 이 균에 의한 감염으로 사망자가 발생했음이 미국 질병통제예방센터(CDC)에 의해 보고됐다. 내성을 극복할 수 있는 새로운 항생제의 개발이 절실히 요구되는 상황이다.연구팀은 생명체 고유의 자기방어 면역시스템이 가지고 있는 항균 펩타이드에 주목했다.

그림. 음성균(대장균·살모넬라균)에 대한 항균 펩토이드 치료제의 다중타겟 메커니즘 효과 교차 검증. 전자현미경, 형광현미경, 3차원 홀로그래피 단층 촬영 현미경을 통한 메커니즘 교차 검증·규명.
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